MyBioSource.com's MOUSE ANTI HUMAN CD126 (IL-6R) is a Mouse monoclonal antibody. The MOUSE ANTI HUMAN CD126 (IL-6R) Antibody was generated using CD126, gp80, IL-6R, IL-6Ralpha, IL6R, IL6R1, IL6RA, and Interleukin 6 Receptor as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, and Immunoprecipitation.
Description
Mouse anti Human CD126 antibody, clone B-R6 recognizes human Interleukin-6 receptor subunit alpha, also known as CD126, IL-6R or Membrane glycoprotein 80. Human CD126 is a 468 amino acid single pass type I transmembrane glycoprotein bearing a single Ig-like C2 type domain, two fibronectin type III domains and a single WSXWS motif which may be involved in receptor avtivation (Daqil et al. 2012). Mouse anti Human CD126 antibody, clone B-R6 inhibits IL-6 mediated proliferation of XG-1 cells (Lu et al. 1995) and partially blocks binding of IL-6 to its receptor (Fourcin et al. 1994), clone B-R6 recognizes both the soluble and membranous human CD126 Removal of Sodium azide is recommended prior to use in functional assays. MyBioSource recommend the use of EQU003 for this purpose